Oligosaccharide Reference Standards
for Quality Control Testing of recombinant glycoprotein pharmaceuticals
TheraProteins offers more than 250 different oligosaccharide (N-glycan) structures of highest purity. Our catalogue contains fully characterized and quantified reference N-linked oligosaccharide structures for use in:
- Quality release testing of pharmaceutical glycoproteins (drug substance and dosage forms)
- Lot-to-lot consistency,
- Stability studies
- In product intermediate analysis
- Primary structural analysis for regulatory file submissions
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More than 70 oligosaccharides standards for recombinant biopharmaceutical glycoprotein profiling / mapping
(quantitative Quality Release Testing of sialylation profile, antennarity, Galß1-4GlcNAc repeat content and others )
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More than 35 N-linked oligosaccharides for recombinant antibody profiling / mapping (Quality testing)
- More than 150 different other oligosaccharides from CHO cells or other cells for N-glycosylation profiling / mapping (Quality testing), for NMR studies or for use as standards in mass spectrometry
- More than 50 different oligosaccharide structures from natural glycoproteins
TheraProteins oligosaccharides are quantified and characterized using complementary methods e.g. validated HPAEC-PAD analysis, ESI-MS (or MALDI-MS). The basic structures are analyzed by NMR spectroscopy.
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Custom services
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N-linked oligosaccharide structure preparation (100µg – 20 mg quantities)
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Including full characterization and quantification of the products
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Glycosylation analysis of total cell glycoprotein
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Analytical service in glycoprotein characterization total cell glycosylation analysis of recombinant cell lines and primary cells
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Supply of glycopeptides with defined N-glycans in 0.1-10 mg quantities
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Glycoprotein primary structural analysis for research purposes
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